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成果及论文
  1. Zhilan Zhou, Yichang Liu, Ya Wang, Hang Jiang, Tingting Chen,Yingdi Zhu, Ting Fu & Juan Li*. Engineering aptamer-directed phosphatase recruiting chimeras: a strategy for modulating receptor function and overcoming drug resistance.Nat Commun,2025,3919. https://doi.org/10.1038/s41467-025-59098-2.（IF:16.6）
  2. Zhilan Zhou, Zening Huang, Yiyuan Tang, Yingdi Zhu, Juan Li*,Modulating membrane-bound enzyme activity with chemical stimuli,European Journal of Medicinal Chemistry, 2024:116964.https://doi.org/10.1016/j.ejmech.2024.116964.(IF:7.1)
  3. Shiqi Jiang, Xinru Lv, Dr. Zhenlin Ouyang, Hongli Chi, Yuchen Zeng, Yani Wang, Jiaxuan He, Jinling Chen, Jingyi Chen, Keli An, Dr. Ming Cheng, Dr. Yurong Wen*, Dr. Juan Li*, Dr. Penghui Zhang*, Programmable Circular Multivalent Nanobody-Targeting Chimeras (mNbTACs) for Multireceptor-Mediated Protein Degradation and Targeted Drug Delivery, Angew. Chem. Int. Ed. 2024, e202407986. https://doi.org/10.1002/anie.202407986.(IF:16.1)
  4. Zhilan Zhou, Tingting Chen, Yingdi Zhu, Lanlan Chen*, Juan Li**,Unlocking cell surface enzymes: A review of chemical strategies for detecting enzymatic activity,Analytica Chimica Acta,1332,2024:343140.https://doi.org/10.1016/j.aca.2024.343140.(IF:6.91)
  5. JIANG Yan, CHEN Yanlin, SONG Gaoyu, CHEN Yanyan, BAI Jing, ZHU Yingdi*, LI Juan*, Bacterial Protein Profiling: Comparison of Three Mass Spectrometry Methodologies, Chem. J. Chinese Universities,2024,45(X),2023:0468.DOI:10.7503/cjcu20240345.(IF:0.7)
  6. Ya Wang, Jie Chen, Sen Zhang, Hang Jiang, Jianqing Zhu, Guangyi Jiang, Yichang Liu, Yingdi Zhu, Juan Li*, Bispecific Nanobody-Aptamer Conjugates for Enhanced Cancer Therapy in Solid Tumors,Small, 2024,2308265. https://doi.org/10.1002/smll.202308265.(IF:13)
  7. Zhilan Zhou, Ya Wang, Zhengtao Shao, Guixi Zhang, Hang Jiang, Yiyuan Tang, Zening Huang, Yingdi Zhu, Juan Li*,A multiparametric fluorescent visualization approach for detecting drug resistance in living cancer cells,Talanta,259,2023:124564.https://doi.org/10.1016/j.talanta.2023.124564.(IF:5.6)
  8. Jia Liu, Qiao Duan, Zhentao Shao, Kaiming Chen, Yingdi Zhu, Juan Li*, and Weihong Tan*,Analytical Chemistry, 2023 ,95 (16),6700-6708.DOI: 10.1021/acs.analchem.3c00434.(IF:7.4)
  9.  Zhentao Shao, Yingdi Zhu and Juan Li*,Bioorthogonal Probes for Analyzing Non-Enzymatic Post-Translational Modifications.ChemBioChem,2023,24,e202200763(1 of 13).DOI: doi.org/10.1002/cbic.202200763 (IF:2.6)
  10. Zhentao Shao, Hui Yuan, Zhilan Zhou, Ya Wang, Peidong Hou, Hexin Nan, Wei Wang, Weihong Tan, and Juan Li*, Angew. Chem. Int. Ed., 2022, 10.1002/anie.202210069. (IF=16.823)
  11. Guanghao Wei,# Rui Hu,*,# Qiuhui Li, Wenlong Lu, Hanyu Liang, Hexin Nan, Jing Lu, Juan Li*, and Qing Zhao*, Oligonucleotide Discrimination Enabled by Tannic Acid-Coordinated Film-Coated Solid-State Nanopores, Langmuir, 2022, 38, 6443-6453. (IF=4.331)
  12. Guangyu Wu, Hanyu Liang, Hexin Nan, Zhentao Shao, Shi Wang, Yan Zhou,* and Juan Li*, One-Step In Situ Self-Assembly of Biodegradable Films for Long-Term Intravesical Bladder Cancer Therapy, ACS Appl. Bio Mater., 2022, 5, 825-832.
  13. Hui Yuan, Hanyu Liang, Peidong Hou, Juan Li*, Advanced Nanomaterials for Multimodal Molecular Imaging, Chem. Res. Chinese Universities, 2021, 37(4), 840-845.
  14. Ya Zhang, Yingjie Wang, Xueqin Yang, Qinglai Yang,* Juan Li*, and Weihong Tan*, Polyaniline Nanovesicles for Photoacoustic Imaging-Guided Photothermal-Chemo Synergistic Therapy in the Second Near-Infrared Window, Small 2020, 2001177. (IF=15.153)
  15.   Wen Yang, Xiaochen Liu, Haofei Li, Jie Zhou, Shan Chen, Pengfei Wang, Juan Li* & Huanghao Yang, Disulfide-Containing Molecular Sticker Assists Cellular Delivery of DNA Nanoassemblies by Bypassing Endocytosis, CCS Chem., 2020, 2, 1178-1186.
  16.  Kaiming Chen, Jie Zhou, Zhentao Shao, Jia Liu, Jia Song, Ruowen Wang*, Juan Li*, and Weihong Tan*, Aptamer as a Versatile Molecular Tool for Antibody Production Monitoring and Quality Control, J. Am. Chem. Soc., 2020, 142, 12079-12086. (IF=16.383)
  17.   Da Zhang, Youshi Zheng, Ziguo Lin, Xiaolong Liu, Juan Li*, Huanghao Yang* and Weihong Tan, Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking for Enhanced Adoptive Immunotherapy in Solid Tumors, Angew. Chem. Int. Ed. 2020, 59, 12022-12028. (IF=16.823)
  18.  Jie Zhou, Zhentao Shao, Jia Liu, Qiao Duan, Xiang Wang, Juan Li*, Huanghao Yang*, From Endocytosis to Nonendocytosis: The Emerging Era of Gene Delivery, ACS Appl. Bio Mater. 2020, 3, 5, 2686-2701.
  19.  Ding Ding, Cai Yang, Cheng Lv, Juan Li*, and Weihong Tan*, Improving Tumor Accumulation of Apteamers by Prolonged Blood Circulation, Anal. Chem., 2020, 92，4108-4114. (IF=8.008)
  20.  Jingying Li, Liping Wang, Jinmiao Tian, Zhilan Zhou, Juan Li*, Yang, Huanghao,* Nongenetic engineering strategies for regulating receptor oligomerization in living cells, Chem. Soc. Rev., 2020, 49, 1545-1568. ( IF=60.615)  
  21.  Jinmiao Tian, Sikai Chen, Xiang Wang and Juan Li*, Evolution of Artificial Base Pairs with Hydrogen Bond Complementarity, Chem. Res. Chinese Universities, 2020, 36, 151-156.
  22.  Yifan Lyu, Ruizi Peng, Hui Liu, Hailan Kuai, Liuting Mo, Da Han, Juan Li* and Weihong Tan*, Protocells programmed through artificial reaction networks, Chem. Sci., 2020, 11, 631-642. (IF= 9.969)
  23.  Shan Chen, Zhifei Xu, Wen Yang, Xiahui Lin, Jingying Li, Juan Li*, and Huanghao Yang, Logic-Gate-Actuated DNA-Controlled Receptor Assembly for the Programmable Modulation of Cellular Signal Transduction, Angew. Chem. Int. Ed., 2019, 58, 18186-18190. (IF=16.823)
  24.  Long Li, Xigao Chen, Cheng Cui, Xiaoshu Pan, Xiaowei Li, Hoda Safari Yazd, Qiong Wu, Liping Qiu, Juan Li*, and Weihong Tan*, Aptamer displacement reaction from live-cell surfaces and its applications, J. Am. Chem. Soc., 2019, 141, 17174-17179. (IF=16.383)
  25.  Da Han, Juan Li, Weihong Tan*, CRISPR propels a smart hydrogel, Science, 2019, 365(6455), 754-755. (IF=41.037)
  26.   Liping Wang, Hong Liang, Jin Sun, Yichang Liu, Jinyu Li, Jingying Li, Juan Li*, Huanghao Yang*, Bispecific Aptamer Induced Artificial Protein-Pairing: A Strategy for Selective Inhibition of Receptor Function, J. Am. Chem. Soc. 2019, 141, 12673-12681. (IF=16.383)
  27.  Xiangyu Ou, Yanyan Chen, Lili Xie, Jie Chen, Jie Zan, Xiaofeng Chen, Zhongzhu Hong, Yu He, Juan Li*, Huanghao Yang,* X-ray Nanocrystal Scintillator-Based Aptasensor for Autofluorescence-Free Detection, Anal. Chem., 2019, 91, 10149-10155. (IF=8.008)
  28.  Jie Zhou, Liqin Sun, Liping Wang, Yichang Liu, Jinyu Li, Jingying Li, Juan Li*, and Huanghao Yang*, Self-Assembled and Size-Controllable Oligonucleotide Nanospheres for Effective Antisense Gene Delivery through an Endocytosis Independent Pathway, Angew. Chem. Int. Ed., 2019, 58, 5236-5240. (IF=16.823)
  29.  Da Zhang, Cuilin Zhang, Shanyou Lan, Yanbing Huang, Jingfeng Liu, Juan Li*, Xiaolong Liu,* and Huanghao Yang*, Near-Infrared Light Activated Thermosensitive Ion Channel to Remotely Control Transgene System for Thrombolysis Therapy, Small, 2019, 1901176. (IF=15.153)
  30.   Kai-Long Zhang, Ying-Jie Wang, Jin Sun, Jie Zhou, Chao Xing, Guoming Huang, Juan Li*, Huanghao Yang*, Artificial chimeric exosomes for anti-phagocytosisand targeted cancer therapy, Chem. Sci., 2019, 10, 1555-1561. (IF=9.969)
  31.  Ding Ding, Da Han, Juan Li*, Weihong Tan*, Improving early detection of cancers by profiling extracellular vesicles, Expert review of proteomics, 2019, 16, 545-547. (IF=2.963)
  32.  Liping Wang, Wei Li, Jin Sun, Su-Yun Zhang, Sheng Yang, Jingying Li, Juan Li*, and Huang-Hao Yang, Imaging of Receptor Dimers in Zebrafish and Living Cells via Aptamer Recognition and Proximity-induced Hybridization Chain Reaction, Anal. Chem., 2018, 90, 14433-14438. (IF=8.008)
  33.  Jingying Li, Shuya Liu, Liqin Sun, Wei Li, Su-Yun Zhang, Sheng Yang, Juan Li*, and Huang-Hao Yang*, Amplified Visualization of Protein-specific Glycosylation in Zebrafish via Proximity-induced Hybridization Chain Reaction, J. Am. Chem. Soc. 2018, 140, 16589-16595. (IF=14.695)
  34.  Shan Chen, Jingying Li, Hong Liang, Xia-Hui Lin, Juan Li* and Huang-Hao Yang*, Light-induced activation of c-Met signalling by photocontrolled DNA assembly, Chem. Eur. J., 2018, 24, 15988-15992. (IF=5.16)
  35.  Jingying Li, Tong Liu, Shuya Liu, Juan Li*, Guoming Huang,* Huang-Hao Yang, Bifunctional magnetic nanoparticles for efficient cholesterol detection and elimination via host-guest chemistry in real samples, Biosens. Bioelectron., 2018, 137-143. (IF=9.518)
  36.  Da Zhang, Zhixiong Cai, Naishun Liao, Shanyou Lan, Ming Wu, Haiyan Sun, Zuwu Wei, Juan Li* and Xiaolong Liu*, pH/hypoxia programmable triggered cancer photo-chemotherapy based on a semiconducting polymer dot hybridized mesoporous silica framework, Chem. Sci., 2018, 9, 7390-7399. (IF=9.556)
  37.  Liping Wang, Peipei Li, Xue Xiao, Jingying Li, Juan Li* ,Huang-Hao Yang*, Weihong Tan, Generating lung-metastatic osteosarcoma targeting aptamers for in vivo and clinical tissue imaging, Talanta, 2018, 188, 66-73. (IF=4.916)
  38.  Xiang-Yu Ou, Tao Guo, Liang Song, Han-Yu Liang, Qi-Zhao Zhang, Jia-Qi Liao, Jing-Ying Li, Juan Li*, and Huang-Hao Yang*, Autofluorescence-free immunoassay using X‑ray scintillating nanotags, Anal. Chem. 2018, 90, 6992-6997. (IF=6.35)
  39. Hong Liang, Shan Chen, Peipei Li, Liping Wang, Jingying Li, Juan Li*, Huang-Hao Yang* and Weihong Tan, Nongenetic approach for imaging protein dimerization by aptamer recognition and proximity-induced DNA assembly, J. Am. Chem. Soc., 2018, 140, 4186-4190. (IF=16.383)
  40. Liang Song, Pei-Pei Li, Wen Yang, Xia-Hui Lin, Hong Liang, Xiao-Feng Chen, Gang Liu, Juan Li* and Huang-Hao Yang*, Low-dose X-ray activation of W(VI)-doped persistent luminescence nanoparticles for deep-tissue photodynamic therapy, Adv. Funct. Mater. 2018, 28, 1707496. (IF=19.924)
  41. Jingying Li, Jie Zhou, Tong Liu, Shan Chen, Juan Li* and Huanghao Yang*, Circular DNA: a stable probe for highly efficient mRNA imaging and gene therapy in living cells, Chem. Commun., 2018, 54, 896-899. (IF=6.065)
  42. Hong Liang, Ying Wu, Xiang-Yu Ou, Jing-Ying Li and Juan Li*, Au@Pt nanoparticles as catalase mimics to attenuate tumor hypoxia and enhance immune cell-mediated cytotoxicity, Nanotechnology, 2017, 28, 465702 (8pp). (IF=3.953)
  43. Cheng-Yi Hong, Shu-Xian Wu, Shi-Hua Li, Hong Liang, Shan Chen, Juan Li*, Huang-Hao Yang,* and Weihong Tan*, Semipermeable functional DNA-encapsulated nanocapsules as protective bioreactors for biosensing in living cells, Anal. Chem., 2017, 89, 5389-5394. (IF=8.008)
  44. Liang Song, Xia-Hui Lin, Xiao-Rong Song, Shan Chen, Xiao-Feng Chen, Juan Li* and Huang-Hao Yang*, Repeatable deep-tissue activation of persistent luminescent nanoparticles by soft X-ray for high sensitivity long-term in vivo bioimaging, Nanoscale, 2017, 9, 2718-2722. (IF=8.307)
  45. Xiao-Rong Song, Shi-Hua Li, Jiayong Dai, Liang Song, Guoming Huang, Ruhui Lin, Juan Li* ,Gang Liu, and Huang-Hao Yang*, Polyphenol-Inspired Facile Construction of Smart Assemblies for ATP- and pH-Responsive Tumor MR/Optical Imaging and Photothermal Therapy, Small, 2017, 13, 1603997. (IF=15.153)
  46. Juan Li * ,Liuting Mo, Chun-Hua Lu, Ting Fu, Huang-Hao Yang* and Weihong Tan*, Functional nucleic acid-based hydrogels for bioanalytical and biomedical applications, Chem. Soc. Rev., 2016, 45, 1410-1431. (IF=60.615)
  47.  Juan Li, Shuxian Wu, Cuichen Wu, Liping Qiu, Guizhi Zhu, Cheng Cui, Yuan Liu, Weijia Hou, Yanyue Wang, Liqin Zhang, I-ting Teng, Huang-Hao Yang* and Weihong Tan*, Versatile surface engineering of porous nanomaterials with bioinspired polyphenol coatings for targeted and controlled drug delivery, Nanoscale, 2016, 8, 8600-8606. (IF=8.307)
  48. Youxiu Lin, Qian Zhou, Juan Li*, Jian Shu, Zhenli Qiu, Yuping Lin, and Dianping Tang*, Magnetic Graphene Nanosheet-Based Microfluidic Device for Homogeneous Real-Time Electronic Monitoring of Pyrophosphatase Activity Using Enzymatic Hydrolysate-Induced Release of Copper Ion, Anal. Chem. 2016, 88, 1030-1038. (IF=8.008)
  49. Juan Li, Cheng-Yi Hong, Shu-Xian Wu, Hong Liang, Li-Ping Wang, Guoming Huang, Xian Chen, Huang-Hao Yang,* Dihua Shangguan,* and Weihong Tan* , Facile phase transfer and surface biofunctionalization ofhydrophobic nanoparticles using Janus DNA tetrahedronnanostructures, J. Am. Chem. Soc. 2015, 137, 11210-11213. (IF=16.383)
  50. Juan Li, Cheng Zheng, Sena Cansiz, Cuichen Wu, Jiehua Xu, Cheng Cui, Yuan Liu, Weijia Hou, Yanyue Wang, Liqin Zhang, I-ting Teng, Huang-Hao Yang*, Weihong Tan*, Self-assembly of DNA nanohydrogels with controllable size and stimuli-responsive property for targeted gene regulation therapy, J. Am. Chem. Soc., 2015, 137, 1412-1415. (IF=16.383)
  51. Kaimei Ke, Lisen Lin, Hong Liang, Xian Chen, Chao Han, Juan Li*, Huang-Hao Yang, Polypyrrole nanoprobes with low non-specific protein adsorption for intracellular mRNA detection and photothermal therapy, Chem. Commun., 2015, 51, 6800-6803. (IF=6.065)
  52. Xiao-Long Zhang, Cheng Zheng, Shan-Shan Guo, Juan Li*, Huang-Hao Yang,* and Guonan Chen, Turn-On Fluorescence Sensor for Intracellular Imaging of Glutathione Using g‑C3N4 Nanosheet-MnO2 Sandwich Nanocomposite, Anal. Chem., 2014, 86, 3426-3434. (IF=8.008)
  53. Li-Sen Lin, Zhong-Xiao Cong, Juan Li*, Kai-Mei Ke, Shan-Shan Guo, Huang-Hao Yang*, Guo-Nan Chen, Graphitic-phase C3N4 nanosheets as efficient photosensitizers and pH-responsive drug nanocarriers for cancer imaging and therapy, J. Mater. Chem. B, 2014, 2, 1031-1037. (IF=7.571)
  54. Juan Li, Fei Jiang, Bo Yang, Xiao-Rong Song, Yan Liu, Wen-Rong Shi*, Dai-Rong Cao*, Huang-Hao Yang*, Guo-Nan Chen. Topological insulator bismuth selenide as a theranostic platform for simultaneous cancer imaging and therapy. Sci. Rep., 2013, 3, 1998.(IF=4.996)
  55.  Juan Li, Ling-Jie Wu, Shan-Shan Guo, Hua-E. Fu, Guo-Nan Chen* and Huang-Hao Yang*. Simple colorimetric bacterial detection and high-throughput drug screening based on a graphene-enzyme complex. Nanoscale, 2013, 5, 619-623. (IF=8.307)
  56. Ai-Xian Zheng, Zhong-Xiao Cong, Jin-Ru Wang, JuanLi*, Huang-HaoYang,* Guo-Nan Chen, Highly-efficient peroxidase-like catalytic activity of grapheme dots for biosensing, Biosens. Bioelectron., 2013, 49, 519-524. (IF=12.545)
  57. Yi-Wei Wang, Yu-Ying Fu, Qiaoli Peng, Shan-Shan Guo, Gang Liu, Juan Li*, Huang-Hao Yang*, Guo-Nan Chen, Dye-enhanced graphene oxide for photothermal therapy and photoacoustic imaging, J. Mater. Chem. B, 2013, 1, 5762-5767. (IF=7.571）
  58. Yi-Wei Wang, Yu-Ying Fu, Ling-Jie Wu, Juan Li*, Huang-Hao Yang,* Guo-Nan Chen, Targeted photothermal ablation of pathogenic bacterium, Staphylococcus aureus, with nanoscale reduced graphene oxide, J. Mater. Chem. B, 2013, 1, 2496-2501. (IF=7.571)
  59.  Juan Li, Hua-E. Fu, Ling-Jie Wu, Ai-Xian Zheng, Guo-Nan Chen, and Huang-Hao Yang*. General colorimetric detection of proteins and small molecules based on cyclic enzymatic signal amplification and hairpin aptamer probe. Anal. Chem., 2012, 84, 5309-5315. (IF=8.008)
  60. Juan Li, Xiu-Juan Qi, Yan-Yan Du, Hua-E Fu, Guo-Nan Chen, Huang-Hao Yang*, Efficient detection of secondary structure folded nucleic acids related to Alzheimer’s disease based on junction probes. Biosens. Bioelectron., 2012, 36, 142-146. (IF=12.545)
  61. Juan Li, Chun-Hua Lu, Qiu-Hong Yao, Xiao-Long Zhang, Jing-Jing Liu, Huang-Hao Yang*, Guo-Nan Chen, A graphene oxide platform for energy transfer-based detection of protease activity. Biosens. Bioelectron., 2011, 26, 3894-3899. (IF=12.545)
  62. Juan Li, Qiu-Hong Yao, Hua-E. Fu, Xiao-Long Zhang, Huang-Hao Yang*, High sensitive and label-free colorimetric DNA detection based on nicking endonuclease-assisted activation of DNAzymes. Talanta, 2011, 85, 91-96. (IF=4.16)
  63. Juan Li, Jinghua Chen, Xiao-Long Zhang, Chun-Hua Lu, Huang-Hao Yang*, A novel sensitive detection platform for antitumor herbal drug aloe-emodin based on the graphene modified electrode, Talanta, 2010, 83, 553-558. (IF=4.16)