1) Cui CY, Li B, Zhang X, Guo SL, Pan BB, Su XC*. Visualization and quantification of base-level SO2 in live cells without intracellular background interference using sensitive 19F-NMR. J. Am. Chem. Soc. 2025, 147, 19893-19901.
2) Zhang X, Li MH, Chen BG, Liu HK, Su XC*. Systematic kinetic assay of phenylsulfonyl pyridine derivatives with free thiol for site-specific modification of proteins. Org. Biomol. Chem. 2025, 23, 4768-4775.
3) Gao Y, Pan BB, Leng Y, Wang XW, Li S, Deng P, Ma Y, Song Y, Su XC*, Yang Y*, Liu Y*. SNAr-based labeling of proteins with trityl radicals enables high-precision, high-sensitivity, and long-range distance measurement. Anal. Chem. 2025, 97, 9256-9264.
4) Wu Q, Yang X, Wang Y, Qin H, Su XC, Xuan W*. Site-selectively accelerating the generation of β-linked residue isoaspartate in proteins. Angew Chem Int Ed Engl. 2025, 64: e202500983.
5) Li MH, Zhang X, Pan BB, Su XC*. Excellent Fe(II) binding tag in protein paramagnetic NMR spectroscopy. Inorg. Chem. 2025, 64, 7890-7901.
6) Gao JM, Li WB, Yi Y, Wei JJ, Gong MX, Pan BB, Su XC, Pan YC*, Guo DS*, Gong QH*. α-Synuclein targeted therapy with multiple pathological improvement for Parkinson's disease by macrocyclic amphiphile nanomedicine. Biomaterials 2025, 322, 123378.
7) Li Z, Xue Y, Duan Y, Yuan W, Chen C, Shi S, Su XC, Kisiswa L*, Fan JS*, Lin Z*. Heterotypic interactions among members of the death domain superfamily with implications for p75NTR-mediated co-signaling. Int. J. Biol. Macromol. 2025, 304, 140791
8) Chen YT, Zhang X, Chen JL, Pan BB, Su XC*. Rigid and stable nitroxide spin label for high-resolution distance measurements on proteins by DEER experiments. Magn. Reson. Lett. 2025, 200194.
9) Chen JL, Chen SN, Liu HK, Pan BB, Zhao Y, Fu X, Otting G, Su XC*. Rational design of lanthanide-binding tags to optimize magnetic anisotropy in paramagnetic protein NMR. J. Am. Chem. Soc. 2025, 147, 9939-9952.
10) Guo SL, Pan BB, Li XY, Xiao YH, Su XC*. 19F-PCS measurements on proteins in live mammalian cells. Chem. Commun. 2025, 61, 1156-1159.
11) Meng WH, Zhang X, Pan BB, Tan X, Zhao JL, Liu Y, Yang Y*, Goldfarb D, Su XC*. Efficient orthogonal spin labeling of proteins via aldehyde cyclization for pulsed dipolar EPR distance measurements. J. Am. Chem. Soc. 2025, 147, 234-246.
12) Mocanu EM, Ben-Ishay Y, Topping L, Fisher SR, Hunter RI, Su XC, Butler SJ, Smith GM, Goldfarb D, Lovett JE*. Robustness and sensitivity of Gd(III)-Gd(III) double electron-electron resonance (DEER) measurements: comparative study of high-frequency EPR spectrometer designs and spin label variants. Appl Magn Reson. 2025, 56, 591-611.
13) Bogdanov A, Gao L, Dalaloyan A, Zhu W, Seal M, Su XC, Frydman V, Liu Y, Gronenborn AM, Goldfarb D*. Spin labels for 19F ENDOR distance determination: resolution, sensitivity and distance predictability. Phys. Chem. Chem. Phys. 2024, 26, 26921-26932.
14) Chen JL, Li B, Yang F, Shi T, Su XC*. Increase of chiral sensing ability in host-guest chemistry by magnetic anisotropy. Since China Chem. 2024, 67, 2775-2782.
15) Yang X, Su XC, Xuan W*. Genetically encoded photocaged proteinogenic and non-proteinogenic amino acids. Chembiochem. 2024, 25, e202400393.
16) Guo SL, Xiao YH, Pan BB, Su XC*. Site-specific anchoring a luminescent tag in a protein with non-emissive Iridium(III) complex. Chembiochem 2024, 25, e202300798.
17) Oranges M, Giannoulis A, Vanyushkina A, Sirkis YF, Dalaloyan A, Unger T, Su XC, Sharon M, Goldfarb D*. C-terminal domain dimerization in yeast Hsp90 is moderately modulated by the other domains. Biophys. J. 2024, 123, 172-184.
18) Ben-Ishay Y, Barak Y, Feintuch A, Ouari O, Pierro A, Mileo E, Su XC, Goldfarb D*. Exploring the dynamics and structure of PpiB in living Escherichia coli cells using electron paramagnetic resonance spectroscopy. Protein Sci. 2024, 33, e4903.
19) Novakovic M, Kim J, Su XC, Kupče ER, Frydman L. Relaxation-assisted magnetization transfer phenomena for a sensitivity-enhanced 2D NMR. Anal. Chem. 2023, 95, 18091-18098.
20) Chen JL, Wang X, Yang F, Li B, Otting G, Su XC*. 3D Structure of the transient intermediate of the enzyme–substrate complex of sortase A reveals how calcium binding and substrate recognition cooperate in substrate activation. ACS Catal. 2023, 13, 11610-11624.
21) Cui CY, Li B, Su XC*. Real time monitoring of the level and activity of intracellular glutathione in live cells at atomic resolution by 19F-NMR. ACS Cent. Sci. 2023, 9, 1623-1632.
22) Yang X, Zhao L, Wang Y, Ji Y, Su XC, Ma JA, Xuan W*. Constructing photoactivatable protein with genetically encoded photocaged glutamic acid. Angew. Chem. Int. Ed. Engl. 2023, 62, e202308472.
23) Li Z, Duan Y, Mao W, Chen C, Yuan W, Jin X, Shi S, Su XC, Ibáñez CF, Lin Z*. Equilibrium between monomers and dimers of the death domain of the p75 neurotrophin receptor in solution. Int. J. Biol. Macromol. 2023, 246, 125710.
24) Chen JL*, Yang Y, Shi T, Su XC*. Effective assessment of lanthanide ion delivery into live cells by paramagnetic NMR spectroscopy. Chem. Comm. 2023, 59, 10552-10555.
25) Wang XW, Zhang X, Cui CY, Li B, Goldfarb D, Yang Y*, Su XC*. Stabilizing nitroxide spin labels for structural and conformational studies of biomolecules by maleimide treatment. Chem. Eur. J. 2023, 29, e202301350.
26) Rogers CJ, Bogdanov A, Seal M, Thornton ME, Su XC, Natrajan LS, Goldfarb D, Bowen AM*. Frequency swept pulses for the enhanced resolution of ENDOR spectra detecting on higher spin transitions of Gd(III). J. Magn. Reson. 2023, 351, 107447.
27) Seal M, Zhu W, Dalaloyan A, Feintuch A, Bogdanov A, Frydman V, Su XC, Gronenborn AM, Goldfarb D. GdIII -19F distance measurements for proteins in cells by electron-nuclear double resonance. Angew. Chem. Int. Ed. Engl. 2023, 62, e202218780.
28) Chen YT, Li B, Chen JL, Su XC*. Stereospecific recognition of a chiral centre over multiple flexible covalent bonds by 19F-NMR. Analyst 2023, 148, 233-238.
29) Pan BB, Liu HZ, Meng WH, Su XC*. Pt(IV) complex selectively oxidizes alpha-synuclein methionine as disclosed by NMR. Inorg. Chem. Front. 2023, 10, 296-304.
30) Su XC*, Zhang LY, Zhao LN, Pan BB, Chen BG, Chen JL, Zhai CL, Li B. Efficient protein-protein couplings mediated by small molecules under mild conditions. Angew. Chem. Int. Ed. Engl. 2022, 61, e202205597.
31) Chen JL, Li B, Ma B, Su XC*. Distinct stereospecific effect of chiral tether between a tag and protein on the rigidity of paramagnetic tag. J. Biomol. NMR 2022, 76, 107-119.
32) Chen YT, Li B, Chen JL, Su XC*. Simultaneous discrimination and quantification of enantiomeric amino acids under physiological conditions by chiral 19F NMR tag. Anal. Chem. 2022, 94, 7853-7860.
33) Zhu W, Guseman AJ, Bhinderwala F, Lu M, Su XC, Gronenborn AM. Visualizing proteins in mammalian cells by 19 F NMR spectroscopy. Angew. Chem. Int. Ed. Engl. 2022, 61, e202201097.
34) Wu X, Ma F*, Pan BB, Zhang Y, Zhu L, Deng F, Xu L, Zhao Y, Yin X, Niu H, Su XC*, Shi L*. Tailoring a nanochaperone to regulate α-synuclein assembly. Angew. Chem. Int. Ed. Engl. 2022, 61, e202200192
35) Cui CY, Li B, Cheng D, Li XY, Chen JL, Chen YT, Su XC*. Simultaneous quantification of biothiols and deciphering diverse GSH stability in different live cells by 19F-tag. Anal. Chem. 2022, 94, 901-908.
36) Chen YT, Li B, Li XY, Chen JL, Cui CY, Hu K, Su XC*. Simultaneous identification and quantification of amino acids in biofluids by reactive 19F-tags. Chem. Commun. 2021, 13154-13157.
37) Fan G, Xu W, Li J, Chen JL, Yu M, Ni Y, Zhu S, Su XC, Cheng F*. Nanoporous NiSb toe Nitrogen electroreduction via tailoring competitive adsorption sites. Adv. Mater. 2021, 33, e2101126.
38) Fan T, Qin R, Zhang Y, Wang J, Fan JS, Bai X, Yuan W, Huang W, Shi S, Su XC, Yang D, Lin Z*. Critical role of minor eggcase silk component in promoting spidroin chain alignment and strong fiber formation. Proc. Natl. Acad. Sci. USA. 2021, 118, e2100496118.
39) Hou XN, Sekiyama N, Ohtani Y, Yang F, Miyanoiri Y, Akagi KI, Su XC, Tochio H*. Conformational space sampled by domain reorientation of linear diubiquitin reflected in its binding mode for target proteins. Chemphyschem. 2021, 22, 1505-1517.
40) Ma B, Chen JL, Cui CY, Yang F, Gong YJ, Su XC.* Rigid, highly reactive and stable DOTA-like tags containing a thiol-specific phenylsulfonyl pyridine moiety for protein modification and NMR analysis. Chem. Eur. J. 2021, 17, 16145-16152.
41) Chen JL, Chen BG, Li B, Yang F, Su XC*. Assessing multiple conformations of lanthanide binding tags for proteins using a sensitive 19F‐reporter. Chem. Commun. 2021, 57, 4291‐4294.
42) Chen JL, Li B, Li XY, Su XC*. Dynamic exchange of the metal chelating moiety: a key factor in determining the rigidity of protein‐tag conjugates in paramagnetic NMR. J. Phys. Chem. Lett. 2020, 11, 9493‐9500
43) Yang Y, Chen SN, Yang F, Li XY, Feintuch A, Su XC*, Goldfarb* D. In‐cell destabilization of a homodimeric protein complex detected by DEER spectroscopy. Proc. Natl. Acad. Sci USA 2020, 117, 20566‐20575
44) Yang Y, Pan BB, Tan X, Yang F, Liu Y*, Su XC*, Goldfarb D*, In‐cell trityl‐trityl distance measurements on proteins. J. Phys. Chem. Lett. 2020, 11, 1141‐1147
45) Giannoulis A, Feintuch A, Barak Y, Mazal H, Albeck S, Unger T, Yang F, Su XC, Goldfarb D*, Two closed ATP ‐ and ADP‐dependent conformations in yeast Hsp90 chaperone detected by Mn(II) EPR spectroscopic techniques. Proc. Natl. Acad. Sci. USA 2020, 117, 395‐404
46) 苏循成. 顺磁标记蛋白质在溶液与细胞内研究中的应用.中国科学‐化学 2019, 49, 1318‐1332.
47) Li M, Ning Y, Chen J, Duan X, Song N, Ding D*, Su X*, Yu Z*. Proline isomerization‐regulated tumor microenvironment‐adaptable self‐assembly of peptides for enhanced therapeutic efficacy. Nano. Lett. 2019, 19, 7965‐79768.
48) Chen JL, Wang X, Xiao YH, Su XC*. Resonance assignments of lowly populated and unstable enzyme intermediate complex under real‐time conditions. Chembiochem. 2019, 20, 2738‐2742.
49) Su XC*, Chen JL. Site‐specific tagging of proteins with paramagnetic ions for determination of protein structures in solution and in cells. Acc. Chem. Res. 2019, 52, 1675‐1686.
50) Chen SN, Fang T, Kong JY, Pan BB, Su XC*. Third BIR domain of XIAP binds to both Cu(II) and Cu(I) in multiple sites and with diverse affinities characterized at atomic resolution. Sci. Rep. 2019, 9, 7428.
51) Pan BB, Yang Y, Liu HZ, Li YH, Su XC*. Coordination of platinum to α‐synuclein inhibits filamentous aggregation in solution. Chembiochem. 2019, 20, 1953‐1958.
52) Giannoulis A, Yang Y, Gong YJ, Tan X, Feintuch A, Carmieli R, Bahrenberg T, Liu Y*, Su XC*, Goldfarb D*. DEER distance measurements on trityl/trityl and Gd(iii)/trityl labelled proteins. Phys. Chem. Chem. Phys. 2019, 21, 10217‐10227.
53) Yang Y, Yang F, Li XY, Su XC*, Goldfarb D*. In‐cell EPR distance measurements on ubiquitin labeled with a rigid PyMTA‐Gd(III) tag. J. Phys. Chem B. 2019, 123, 1050‐1059.
54) Wang X, Chen JL, Otting G, Su XC*. Conversion of an amide to a high‐energy thioester by Staphylococcus aureus sortase A is powered by variable binding affinity for calcium. Sci. Rep. 2018, 8, 16371.
55) Yang Y, Yang F, Gong YJ, Bahrenberg T, Feintuch A, Su XC*, Goldfarb D*. High sensitivity in‐cell EPR distance measurements on proteins using an optimized Gd(III) spin label. J. Phys. Chem. Lett. 2018, 9, 6119‐6123.
56) Xu D, Li B, Gao J, Liu Z, Niu X, Nshogoza G, Zhang J, Wu J, Su XC, He W, Ma R, Yang D, Ruan K. Ligand proton pseudocontact shifts determined from paramagnetic relaxation dispersion in the limit of NMR intermediate exchange. J. Phys. Chem. Lett. 2018, 9, 3361‐3367.
57) Chen JL, Zhao Y, Gong YJ, Pan BB, Wang X, Su XC*. Stable and rigid DTPA‐like paramagnetic tags suitable for in vitro and in situ protein NMR analysis. J. Biomol. NMR 2018, 70, 77‐92.
58) Hou MM, Polykretis P, Luchinat E, Wang X, Chen SN, Zuo HH, Yang Y, Chen JL, Ye Y, Li C, Banci L*, Su XC*. Solution structure and interaction with copper in vitro and in living cells of the first BIR domain of XIAP. Sci. Rep. 2017, 7, 16630.
59) Li X, Wu G, Yang Y, Fu S, Liu X, Kang H, Yang X*, Su XC*, Shen Y*. Calmodulin dissociates the STIM1‐Orial complex and STIM1 oligomers. Nat. Commun. 2017, 8, 1042.
60) Gao J, Liang E, Ma R, Li F, Liu Y, Liu J, Jiang L, Li C, Dai H, Wu J, Su XC, He W*, Ruan K*. Fluorine pseudocontact shifts used for characterizing the protein‐ligand interaction mode in the limit of NMR intermediate exchange. Angew. Chem. Int. Ed. Engl. 2017, 56, 12982‐12986.
61) Yang Y, Gong YJ, Litinov A, Liu HK, Yang F, Su XC*, Goldfarb D*. Generic Tags for Mn(II) and Gd(III) spin labels for distance measurements in proteins. Phys. Chem. Chem. Phys. 2017, 19, 26944‐26956.
62) Cao C, Wang S, Cui T, Su XC*, Chou J*. Ion and inhibitor binding of the double‐ring ion selectivity filter of the Mitochondrial calcium uniporter. Proc. Natl. Acad. Sci. USA 2017, 114, E2846‐E2851.
63) Yang Y, Yang F, Gong YJ, Chen Jl., Goldfarb D*, Su XC*. A reactive, rigid Gd(III) labelling tag for in‐cell EPR distance measurements in proteins. Angew. Chem. Int. Ed. Engl. 2017, 56, 2914‐2918.
64) Ma FH, Wang X, Chen JL, Wen X, Sun H*, Su XC*. Deciphering the multisite interactions of a protein and its ligand at atomic resolution by using sensitive paramagnetic effects. Chem. Eur. J. 2017, 23, 926‐934.
65) Li ML, Yang S, Su XC, Wu HL, Yang LL, Zhu SF, Zhou QL*. Mechanism studies of Ir‐catalyzed asymmetric hydrogenation of unsaturated carboxylic acids. J. Am. Chem. Soc. 2017, 139, 541‐547.
66) Chen JL, Wang X, Yang F, Cao C, Otting G, Su XC*. 3D Structure determination of an unstable transient enzyme intermediate by paramagnetic NMR spectroscopy. Angew. Chem. Int. Ed. Engl. 2016, 55, 13744‐13748.
67) Yang F, Wang X, Pan BB, Su XC*. Single‐armed phenylsulfonated pyridine derivative of DOTA is rigid and stable paramagnetic tag in protein analysis. Chem. Commun. 2016, 52, 11535‐11538.
68) Pan BB, Yang F, Ye Y, Wang JT, Li C*, Huber T*, Su XC*. Structural determination of proteins in living cells by paramagnetic NMR spectroscopy. Chem. Commun. 2016, 52, 10237‐10240.
69) Ma RS, Li QF, Wang AD, Zhang JH, Liu ZJ, Wu JH, Su XC*, Ruan K*. Determination of pseudocontact shifts of low‐populated excited states by NMR chemical exchange saturation transfer. Phys. Chem. Chem. Phys. 2016, 18, 13794‐13798.
70) Yang Y, Huang F, Huber T, Su XC*. Site‐specific tagging proteins with a rigid, small and stable transition metal chelator 8‐hydroxyquinoline for paramagnetic NMR analysis. J. Biolmol. NMR 2016, 64, 102‐113.
71) Chen JL, Yang Y, Zhang LL, Liang H, Huber T*, Su XC*, Otting G*. Analysis of the solution conformations of T4 lysozyme by paramagnetic NMR spectroscopy. Phys. Chem. Chem. Phys. 2016, 18, 5850‐5859.
72) Martorana A, Yang Y, Zhao Y, Li QF, Su XC*, Goldfarb D*. Mn(II) tags for DEER distance measurements in proteins via C‐S attachment. Dalton 2015, 44, 20812‐20816.
73) Yang Y, Wang JT, Pei YY, Su XC*. Site‐specific tagging proteins via a rigid, stable and short thiolether tether for paramagnetic spectroscopic analysis. Chem. Commun. 2015, 51, 2824‐2827.
74) Wang Z, Yang X, Guo S, Yang Y, Su XC, Shen Y, Long J. Crystal structure of the ubiquitin‐like domain‐CUT repeat‐like tandem of special AT‐rich sequence binding protein 1 (SATB1) reveals a coordinating DNA‐binding mechanism. J. Biol. Chem. 2014, 289, 27376‐27385.
75) Cao C, Chen JL, Yang Y, Huang F, Otting G, Su XC*. Selective 15N‐labeling of the side‐chain amide groups of asparagine and glutamine for applications in paramagnetic NMR spectroscopy. J. Biomol. NMR 2014, 59, 251‐261.
76) Ma FH, Chen JL, Li QF, Su XC*. Kinetic assay of Michael addition like thiol‐ene reaction and the insight into protein bioconjugation. Chem. Asian J. 2014, 9, 1808‐1816.
77) Yang Y, Chen JL, Su XC*. PCS in structural biology. Chin. J. Magn. Reson. (杨茵,陈家良,苏循成*. 蛋白质顺磁标记技术与生物核磁共振中的赝接触位移,波谱学杂志) 2014, 31, 155‐171.
78) Su XC, Wang Y, Yagi H, Shishmarev D, Mason CE, Smith PJ, Vandevenne M, Dixon NE, Otting G*. Bound or free: interaction of the C‐terminal domain of Escherichia coli single‐stranded DNA‐binding protein (SSB) with the tetrameric core of SSB. Biochemistry 2014, 52, 1925‐1934.
79) Shishmarev D, Wang Y, Mason CE, Su XC, Oakley AJ, Graham B, Huber T, Dixon NE, Otting G*. Intramolecular binding mode of the C‐terminus of Escherichia coli single‐stranded DNA binding protein determined by nuclear magnetic resonance spectroscopy. Nucleic Acids Res. 2014, 42, 2750‐2757.
80) Huang F, Pei YY, Zuo HH, Chen JL, Su XC*. Bioconjugation of proteins with a paramagnetic NMR and fluorescent tag. Chem. Eur. J. 2013, 19, 17141‐17149.
81) Wei Z, Yang Y, Li QF, Huang F, Zuo HH, Su XC*. Noncovalent tagging proteins with paramagnetic lanthanide complexes for protein study. Chem. Eur. J. 2013, 19, 5758‐5764.
82) Yang Y, Li QF, Cao C, Huang F, Su XC*. Site‐specific labeling of proteins with a chemically stable, high‐affinity tag for protein study. Chem. Eur. J. 2013, 19, 1097‐1013.
83) Li J, Pilla KB, Li QF, Zhang Z, Su XC, Huber T, Yang J*. Magic angle spinning NMR structure determination of proteins from pseudocontact shifts. J. Am. Chem. Soc. 2013, 135, 8294‐8303.
84) Zhou JY, Wan XJ, Liu YS, Zuo Y, Li Z, He GR, Long GK, Ni W, Li CS, Su XC, Chen YS*. Small molecules based on benzo[1,2‐b:4,5‐b '] dithiophene unit for high‐performance solution‐processed organic solar cells. J. Am. Chem. Soc. 2012, 134, 16345‐16351.
85) Li QF, Yang Y, Maleckis A, Otting G*, Su XC*. Thiol‐ene reaction: a versatile tool in site‐specific labelling of proteins with chemically inert tags for paramagnetic NMR. Chem. Commun. 2012, 48, 2704‐2706.